Toxicity of Therapy with Sm-153-EDTMP: To what Extend can it be Related to the Tumor Type?
نویسندگان
چکیده
منابع مشابه
Lu - DOTMP , 153 Sm - DOTMP , 175 Yb - EDTMP and 186 / 188 Re - CTMP : Novel Agents for Bone Pain Palliation and Their Comparison with 153 Sm - EDTMP
Designing ideal radiopharmaceuticals for use as bone pain palliatives require the use of a moderate energy β emitter with a stable carrier molecule. Cyclic polyaminophosphonate ligands are known to form complexes with higher thermodynamic stability and kinetic inertness. The present study therefore envisages the use of a few moderate energy β emitters, viz. Lu (T1/2 = 6.71 d, Eβmax= 497 keV), S...
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Forty dogs with spontaneous skeletal neoplasia were treated with 153Sm-EDTMP (ethylenediaminetetramethylene phosphonic acid). Both primary and metastatic lesions were treated. Two treatment regimes, a single (37 MBq (1.0 mCi)/kg dose or two 37 MBq (1.0 mCi)/kg doses separated by 1 wk) were tested. Response to treatment was varied. Large lesions with minimal tumor bone formation responded poorly...
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Introduction: Nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. Among those, Sm-ethylenediamine tetramethylene phosphonic acid (Sm-EDTMP) is the major therapeutic agent which is widely used in the world. In this study, production, quality control and biodistribution studies of this therapeutic radiopharmaceutical have been presented and followed b...
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Nine dogs with primary bone tumours were treated with Samarium-153-EDTMP (Sm-153-EDTMP). Conventional treatment protocols were precluded by the size of the dogs and the owners' refusal of limb amputation. All the tumours were of the appendicular skeleton; 4 were confirmed osteosarcomas. The other 5 tumours were radiologically suspect for osteosarcoma. Bone scans were performed on all dogs using...
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ژورنال
عنوان ژورنال: World Journal of Nuclear Medicine
سال: 2015
ISSN: 1450-1147
DOI: 10.4103/1450-1147.167603